Barbara S Slusher Selected Research

Diazooxonorleucine

11/2019	Tumor-Targeted Delivery of 6-Diazo-5-oxo-l-norleucine (DON) Using Substituted Acetylated Lysine Prodrugs.
11/2019	Glutamine antagonism attenuates physical and cognitive deficits in a model of MS.
10/2019	Unbiased Metabolic Profiling Predicts Sensitivity of High MYC-Expressing Atypical Teratoid/Rhabdoid Tumors to Glutamine Inhibition with 6-Diazo-5-Oxo-L-Norleucine.
1/2019	JHU-083 selectively blocks glutaminase activity in brain CD11b+ cells and prevents depression-associated behaviors induced by chronic social defeat stress.
1/2019	Glutamine Antagonist JHU083 Normalizes Aberrant Glutamate Production and Cognitive Deficits in the EcoHIV Murine Model of HIV-Associated Neurocognitive Disorders.
12/2018	MRI demonstrates glutamine antagonist-mediated reversal of cerebral malaria pathology in mice.
1/2017	N-(Pivaloyloxy)alkoxy-carbonyl Prodrugs of the Glutamine Antagonist 6-Diazo-5-oxo-l-norleucine (DON) as a Potential Treatment for HIV Associated Neurocognitive Disorders.
1/2017	Glutamine antagonist-mediated immune suppression decreases pathology but delays virus clearance in mice during nonfatal alphavirus encephalomyelitis.
10/2016	Protective Effects of Glutamine Antagonist 6-Diazo-5-Oxo-l-Norleucine in Mice with Alphavirus Encephalomyelitis.
9/2016	Discovery of 6-Diazo-5-oxo-l-norleucine (DON) Prodrugs with Enhanced CSF Delivery in Monkeys: A Potential Treatment for Glioblastoma.

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Barbara S Slusher Research Topics

Disease

40	Neoplasms (Cancer) 04/2022 - 06/2004
12	Neuralgia (Stump Neuralgia) 01/2017 - 02/2002
11	Peripheral Nervous System Diseases (PNS Diseases) 01/2018 - 10/2005
10	Infections 10/2022 - 06/2013
8	Cognitive Dysfunction 10/2022 - 12/2012
8	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2022 - 03/2011
8	Nervous System Diseases (Neurological Disorders) 01/2022 - 05/2010
8	Nausea 12/2015 - 09/2006
8	Vomiting 12/2015 - 09/2006
7	Inflammation (Inflammations) 10/2022 - 10/2003
7	Prostatic Neoplasms (Prostate Cancer) 06/2020 - 06/2004
6	Glioblastoma (Glioblastoma Multiforme) 10/2021 - 01/2009
6	Alzheimer Disease (Alzheimer's Disease) 11/2020 - 04/2011
6	Schizophrenia (Dementia Praecox) 05/2016 - 06/2005
5	Pain (Aches) 01/2022 - 12/2012
5	Neurocognitive Disorders (Clerambault Syndrome) 09/2021 - 06/2013
5	Glioma (Gliomas) 01/2021 - 01/2009
5	Hyperalgesia 12/2018 - 02/2002
5	Neuroinflammatory Diseases 01/2018 - 06/2014
4	Medulloblastoma 03/2022 - 10/2019
4	Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease) 01/2022 - 06/2003
4	Breast Neoplasms (Breast Cancer) 02/2021 - 06/2011
4	Inflammatory Bowel Diseases (Inflammatory Bowel Disease) 06/2020 - 08/2016
4	Opioid-Related Disorders (Opiate Addiction) 01/2019 - 03/2003
4	Multiple Sclerosis 01/2015 - 12/2012
3	Brain Injuries (Brain Injury) 12/2021 - 10/2005
3	Substance-Related Disorders (Drug Abuse) 10/2019 - 07/2015
3	Mental Disorders (Mental Disorder) 10/2019 - 02/2017
3	Wounds and Injuries (Trauma) 01/2018 - 12/2012
3	Encephalomyelitis (Myeloencephalitis) 01/2017 - 04/2015
3	Dementia (Dementias) 01/2014 - 09/2009
2	HIV Infections (HIV Infection) 08/2022 - 06/2013
2	Rhabdoid Tumor (Rhabdoid Tumors) 04/2022 - 10/2019
2	Virus Diseases (Viral Diseases) 01/2022 - 04/2015
2	Canavan Disease (Leukodystrophy, Spongiform) 01/2022 - 01/2021
2	Autosomal Dominant Polycystic Kidney (ADPKD) 10/2020 - 01/2018
2	Neurofibromatosis 1 (Neurofibromatosis Type I) 01/2020 - 01/2019
2	Brain Neoplasms (Brain Tumor) 01/2020 - 01/2015
2	Hypoxia (Hypoxemia) 11/2019 - 01/2012
2	Experimental Autoimmune Encephalomyelitis (Encephalomyelitis, Autoimmune Experimental) 11/2019 - 12/2012
2	Pancreatic Neoplasms (Pancreatic Cancer) 11/2019 - 01/2016
2	Lymphoma (Lymphomas) 11/2019 - 12/2012
2	Carcinogenesis 11/2019 - 06/2015

Drug/Important Bio-Agent (IBA)

31	Glutamic Acid (Glutamate)FDA Link 08/2022 - 02/2002
30	Glutamine (L-Glutamine)FDA Link 03/2022 - 11/2010
23	Glutamate Carboxypeptidase II (N-Acetylaspartylglutamate Peptidase)IBA 10/2022 - 02/2002
16	ProdrugsIBA 01/2022 - 09/2016
12	Pharmaceutical PreparationsIBA 01/2022 - 03/2006
11	GlutaminaseIBA 01/2021 - 11/2010
11	DiazooxonorleucineIBA 11/2019 - 04/2015
8	AcidsIBA 10/2021 - 02/2002
8	EnzymesIBA 01/2021 - 12/2005
7	Palonosetron (Aloxi)FDA Link 12/2015 - 01/2010
6	Sphingomyelin Phosphodiesterase (Sphingomyelinase)IBA 12/2021 - 01/2015
6	Proteins (Proteins, Gene)FDA Link 01/2021 - 04/2011
5	LigandsIBA 06/2020 - 11/2010
5	Dopamine D3 ReceptorsIBA 10/2019 - 07/2015
5	Paclitaxel (Taxol)FDA LinkGeneric 01/2018 - 05/2010
5	eribulin FDA Link 01/2018 - 06/2011
5	Analgesics (Analgesic Drugs)IBA 01/2017 - 02/2002
5	AntigensIBA 12/2012 - 06/2004
4	metabotropic glutamate receptor 3 (mGluR3)IBA 10/2022 - 10/2003
4	Glutathione (Reduced Glutathione)IBA 03/2022 - 01/2019
4	2-(phosphonomethyl)pentanedioic acidIBA 10/2017 - 09/2002
4	Antineoplastic Agents (Antineoplastics)IBA 01/2016 - 05/2010
4	Serotonin (5 Hydroxytryptamine)IBA 01/2014 - 06/2005
4	Substance PIBA 08/2012 - 09/2006
3	JHU083IBA 08/2022 - 01/2019
3	Mechanistic Target of Rapamycin Complex 1IBA 04/2022 - 01/2019
3	Amino Acids FDA Link 03/2022 - 01/2016
3	CeramidesIBA 01/2022 - 05/2019
3	isospaglumic acid (NAAGA)IBA 01/2021 - 02/2002
3	Messenger RNA (mRNA)IBA 01/2021 - 08/2003
3	Opioid Analgesics (Opioids)IBA 01/2019 - 12/2005
3	N-Methylaspartate (NMDA)IBA 01/2016 - 09/2002
3	TachykininsIBA 01/2014 - 06/2012
3	Neurokinin-1 Receptors (Neurokinin 1 Receptor)IBA 01/2014 - 06/2012
3	Small Interfering RNA (siRNA)IBA 01/2014 - 11/2010
2	Metabotropic Glutamate Receptors (Metabotropic Glutamate Receptor)IBA 10/2022 - 01/2010
2	CarbonIBA 03/2022 - 01/2020
2	NucleotidesIBA 03/2022 - 02/2021
2	HexosaminesIBA 03/2022 - 02/2021
2	Glucose (Dextrose)FDA LinkGeneric 03/2022 - 01/2012
2	G-Protein-Coupled Receptors (Receptors, G Protein Coupled)IBA 01/2022 - 01/2019
2	pyrenedodecanoylcarnitineIBA 01/2022 - 12/2021
2	DNA (Deoxyribonucleic Acid)IBA 10/2021 - 01/2019
2	Temozolomide (Temodar)FDA LinkGeneric 10/2021 - 01/2009
2	JHU395IBA 01/2021 - 01/2020
2	Phosphotransferases (Kinase)IBA 01/2021 - 05/2014
2	Isocitrate Dehydrogenase (Isocitrate Dehydrogenase (NAD+))IBA 01/2021 - 11/2010
2	purineIBA 01/2021 - 01/2020
2	Carboplatin (JM8)FDA LinkGeneric 01/2021 - 01/2019
2	Biological ProductsIBA 01/2020 - 06/2011
2	IsotopesIBA 01/2020 - 01/2012
2	Lysine (L-Lysine)FDA Link 11/2019 - 12/2012

Therapy/Procedure

22	Therapeutics 08/2022 - 01/2009
20	Drug Therapy (Chemotherapy) 01/2021 - 09/2006
4	Oral Administration 01/2014 - 05/2003
2	Radiotherapy 06/2020 - 01/2009
2	Immunotherapy 01/2020 - 11/2019